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张晓茹

发布时间:2014-02-28


       张晓茹:女,1974年7月生,博士,教授,硕士生导师。于天津大学获学士和硕士学位,2003年毕业于中国海洋大学药物所获博士学位。早期从事糖类化合物的合成研究,目前主要从事生物活性物质的检测,包括DNA、癌细胞、酶、小分子活性物质及重金属离子等。研究内容涉电化学、化学发光、荧光及光致电化学等。同时开展了新型功能化材料的研究如碳纳米管、石墨烯等。作为项目负责人承担国家自然科学基金两项:利用光致电化学方法实现与糖类抗原相关的肿瘤标志物的高灵敏检测(21275003,青年-面上连续资助),80万元;基于核酸适体的光致电化学传感器的研究(20905040,青年基金),23万元。山东省中青年科学家奖励基金一项:基于石墨烯的光致电化学传感器的制备及其在肿瘤标志物检测中的应用(BS2011CL015),6万元。中国海洋大学海洋药物教育部重点实验室开放基金(KLMD(OUC)201206),3万元。山东大学微生物技术国家重点实验室开放基金(M2013-13),2万元。获山东省高校科研成果三等奖一项(第一获奖人),获山东省高校科研成果一等奖一项(第二获奖人)。作为第一作者发表SCI论文20余篇,其中影响因子大于5.0的SCI论文14篇。作为第一发明人授权国家发明专利一项(ZL201110021525.X)。参编《有机化学》和《有机化学实验》教材2部,参编《现代芳烃化学-概念、合成及应用》、《有机合成-概念与方法》和《多组分反应》译著3部。

联系方式:

电话:15064250022,邮箱:zhangxr7407@126.com

(1) Xiaoru Zhang, Hongxia Liu, Ruijuan Li, Ningbo Zhang, Ying Xiong, Shuyan Niu. Chemiluminescence detection of DNA/microRNA based on cation-exchange of CuS nanoparticles and rolling circle amplification, Chem. Commun., 2015, DOI: 10.1039/c5cc01317h. (IF 6.718)

(2) Xiaoru Zhang, Jiao Chen, Hongxia Liu, Shusheng Zhang. Quartz crystal microbalance detection of protein amplified by nicked circling, rolling

circle amplification and biocatalytic precipitation, Biosensors and Bioelectronics ;65 (2015) 341–345. (IF 6.451)

(3) Xiaoru Zhang, Mingshuai Liu, Yaning Mao, Yunpeng Xu, Shuyan Niu. Ultrasensitive photoelectrochemical immunoassay of antibody against tumor-associated carbohydrate antigen amplified by functionalized graphene derivates and enzymatic biocatalytic precipitation.

Biosensors and Bioelectronics 59 (2014) 21–27. (IF 6.451)

(4) Xiaoru Zhang, Mingshuai Liu, Hongxia Liu, Shusheng Zhang, Low-toxic Ag2S quantum dots for photoelectrochemical detection glucose and cancer cells. Biosensors and Bioelectronics 56 (2014) 307–312. (IF 6.451)

(5) Xiaoru Zhang, Yunpeng Xu, Yanqing Zhao, Weiling Song, A new photoelectrochemical biosensors based on DNA conformational changes and

isothermal circular strand-displacement polymerization reaction, Biosensors and Bioelectronics, 2013, 39, 338–341. (IF 6.451).

(6) Xiaoru Zhang, Yunpeng Xu, Yanqiang Yang, Xia Jin, Sujuan Ye, Shusheng Zhang, and Lilin Jiang. New Signal-On Photoelectrochemical Biosensor Based on a Graphene/Quantum-Dot Nanocomposite Amplified by the Dual- Quenched Effect of Bipyridinium Relay and AuNPs,Chem. Eur. J. 2012, 18, 16411 – 16418. (IF 5.696).

(7) Xiaoru Zhang, Shuguo Li, Xia Jin, Shusheng Zhang, A new photoelectrochemical aptasensor for the detection of thrombin based on functionalized

graphene and CdSe nanoparticles multilayers, Chem. Commun., 2011, 47, 4929–4931. (IF 6.718).

(8) Xiaoru Zhang, Yanqing Zhao, Shuguo Li, Shusheng Zhang, Photoelectrochemical biosensor for detection of adenosine triphosphate in the extracts of

cancer cells, Chem. Commun., 2010, 46, 9173–9175. (IF 6.718).

(9) Xiaoru Zhang, Huanran Zhou, Caifeng Ding, Shusheng Zhang, A dicopper complex chemiluminescence probe for the determination of thiols in the

extracts of murine P388 lymphocytic leukemia cell, Chem Commun, 2009, 5624-5626. (IF6.718).

(10) Xiaoru Zhang, Yanqing Zhao, Huanran Zhou, Bin Qu, A new strategy for photoelectrochemical DNA biosensor using chemiluminescence reaction

as light source, Biosensors and Bioelectronics 26 (2011) 2737–2741. (IF 6.451).

(11) Xiaoru Zhang, Shuguo Li, Xia Jin, Xuemei Li, Aptamer based photoelectrochemical cytosensor with layer-by-layer assembly of CdSe semiconductor nanoparticles as photoelectrochemically active species, Biosensors and Bioelectronics 26 (2011) 3674–3678. (IF 6.451).

(12) Xiaoru Zhang, Haoran Su, Sai Bi, Shuguo Li, Shusheng Zhang, DNA-based amplified electrical bio-barcode assay for one-pot detection of two target DNAs, Biosensors and Bioelectronics, 2009, 24(8), 2730-2734. (IF 6.451).

(13) Xiaoru Zhang, Ying Li, Haoran Su, Shusheng Zhang, Highly sensitive and selective detection of Hg2+ using mismatched DNA and a molecular light switch

complex in aqueous solution. Biosensors and Bioelectronics, 2010, 25(6), 1338-1343. (IF6.451).

(14) Xiaoru Zhang, Baoping, Qi, Shusheng Zhang, Amplified electrochemical aptasensor for thrombin based on bio-barcode method, Biosensors and Bioelectronics, 2009, 25,259-262. (IF 6.451).

(15) Xiaoru Zhang, Yingshu Guo, Mingshuai Liu and Shusheng Zhang, Photoelectrochemically active species and photoelectrochemical biosensors,

RSC Adv., 2013, 3, 2846–2857. (IF 3.708)

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