所属院系

化学与分子工程学院

导师类别

博士生导师、硕士生导师

招生专业

化学、基础医学、材料学等相关专业

研究方向

生命分析，分子影像，纳米医学

联系方式

 zhangps@qust.edu.cn

个人简历（包括近期科研项目）

张沛森，博士，青岛科技大学化学与分子工程学院特聘教授，博士生导师，泰山学者青年专家。2015年获中南大学应用化学学士学位，2020年毕业于中国科学院化学研究所，获物理化学博士学位，2021-2023年于广州市第一人民医院/华南理工大学从事博士后研究。主要从事纳米探针的设计及其对重大疾病的多模态精准影像诊断和治疗研究。迄今，以第一/通讯作者在Nat. Commun.，Sci. Adv.，Angew. Chem. Int. Ed.，ACS Nano，Adv. Funct. Mater.，Biomaterials，Anal. Chem.，Innovation等国际重要期刊发表论文40余篇，合著发表论文60余篇。

科研项目

国家自然科学基金面上项目（2025-2028），主持

泰山学者青年专家项目（2025-2027），主持

国家重点研发计划青年科学家项目（2024-2029），项目骨干

国家自然科学基金青年项目（2022-2024），主持

中国博士后科学基金面上资助（2021-2023），主持

青岛科技大学人才引进启动资金（2024-2029），主持

代表性论文

1. Wenyue Li, Junwei Cheng, Chuang Liu, Ni Zhang, Hua Lin, Fangfei He, Zhihua Gan, Peisen Zhang*, Meng Qin*, Yi Hou*. Shine and darkle the blood vessels: Multiparameter hypersensitive MR angiography for diagnosis of panvascular diseases. Sci. Adv., 2024, 10, eadq4082.

2. Peisen Zhang#, Junwei Cheng#, Yijie Lu#, Ni Zhang, Xiaoai Wu, Hua Lin, Wei Li*, Jian Wang, Mitchell A. Winnik, Zhihua Gan*, Yi Hou*. Hypersensitive MR Angiography based on Interlocking Stratagem for Diagnosis of Cardiac-cerebral Vascular Diseases. Nat. Commun., 2023, 14, 6149.

3. Peisen Zhang#, Jianfeng Zeng#, Yingying Li, Chen Yang, Junli Meng, Yi Hou*, Mingyuan Gao* Quantitative Mapping of Glutathione within Intracranial Tumors through Interlocked MRI Signals of a Responsive Nanoprobe. Angew. Chem. Int. Ed., 2021, 60, 8130-8138.

4. Peisen Zhang, Yi Hou*, Jianfeng Zeng, Yingying Li, Zihua Wang, Ran Zhu, Tiancong Ma, Mingyuan Gao*. Coordinatively Unsaturated Fe3+ Based Activatable Probes for Enhanced MRI and Therapy of Tumors. Angew. Chem. Int. Ed., 2019, 58, 11088-11096.

5. Peisen Zhang, Lichong Zhu, Wenyue Li, Qiuhong Ouyang, Saisai Yue, Meng Qin, Yi Hou*. Simultaneous Visualization of Anatomical Structure and Molecular Pathology Variation in Vascular Inflammation with Informationized Serum Albumin. ACS Nano, 2025, 19, 22109-22122.

6. Mingxia Jiao, Xiaoqi Li, Hui Liu, Peng Cai, Xiling Yang, Kevin J. McHugh, Bowen Zheng, Jiachen Sun, Peisen Zhang*, Xiliang Luo*, Lihong Jing*. Aqueous Grown Quantum Dots with Robust Near-Infrared Fluorescence for Integrated Traumatic Brain Injury Diagnosis and Surgical Monitoring. ACS Nano, 2024, 18, 19038-19053.

7. Wenyue Li, Junwei Cheng, Xinyi Zhang, Yuqing Wang, Shuai Wu, Peisen Zhang*, Zhihua Gan, Yi Hou*. High-Resolution Magnetic Resonance Angiography of Tumor Vasculatures with an Interlocking Contrast Agent. ACS Nano, 2024, 18, 25647-25656.

8. Peisen Zhang#, Yuanyuan Qiao#, Lichong Zhu, Meng Qin, Qilong Li, Chuang Liu, Yuping Xu, Xin Zhang, Zhihua Gan*, Yi Hou*. Nanoprobe Based on Biominerals in Protein Corona for Dual-Modality MR Imaging and Therapy of Tumors. ACS Nano, 2023, 17, 184-196.

9. Saisai Yue, Peisen Zhang*, Meng Qin, Lichong Zhu, Yuanyuan Qiao, Qilong Li, Yijie Lu, Hao Wu, Ni Jiang, Chaoyong Liu, Mitchell A. Winnik*, Yi Hou*. An Enzyme-Like Activity Nanoprobe Based on Fe(III)–Rutin Hydrate Biomineral for MR Imaging and Therapy of Triple Negative Breast Cancer. Adv. Funct. Mater., 2022, 32, 2202848.

10. Peisen Zhang, Yi'an Ran, Lei Han, Yao Li, Wanru Tian, Xiao Sun, Mingxia Jiao*, Lihong Jing*, Xiliang Luo*. Nanomaterial technologies for precision diagnosis and treatment of brain hemorrhage. Biomaterials, 2025, 321, 123269.

11. Wenyue Li, Mingxia Jiao, Yao Li, Shuai Wu, Peisen Zhang*, Xiliang Luo*, Yi Hou*. Hypersensitive Multiparametric MRA for Mild Traumatic Brain Injury: Simultaneous Imaging of Hemorrhagic Foci, Vascular Integrity, and Collaterals. Anal. Chem., 2025, 97, 13021-13030.

12. Peisen Zhang#, Junwei Cheng#, Chuang Liu#, Wenyue Li, Yuqing Wang, Ni Zhang, Jin Wu, Xinyu Zhang, Chaoyong Liu, Yi Hou*. Hypersensitive MR Angiography for Diagnosis of Ischemic Stroke and Reperfusion Subarachnoid Hemorrhage. Anal. Chem., 2024, 96, 11742-11750.

13. Lina Zhu#, Yuxi Zhang#, Jiani Ding, Wenjuan Xin, Gao-Chao Fan, Zhi-Ling Song*, Peisen Zhang*, Xiliang Luo*. Intelligent DNA Nanosystem for Broad-Spectrum Oncological Typing and Therapy. ACS Sens., 2024, 9, 6655-6666.

14. Xiao Sun#, Wanru Tian#, Xin Zhao, Xuan Cheng, Yao Li, Qiye Wang, Weichen Li, Peisen Zhang*, Mingxia Jiao*, Xiliang Luo*. Aqueous Gallium-doped Copper Indium Selenide Quantum Dots for Non-invasive Severity Grading of Traumatic Brain Injury. Adv. Healthc. Mater., 2025, DOI: 10.1002/adhm.202502911.

15. Peisen Zhang, Junli Meng, Yingying Li, Chen Yang, Yi Hou, Wen Tang, Kevin J. McHugh*, and Lihong Jing*, Nanotechnology-enhanced immunotherapy for metastatic cancer. Innovation, 2021, 2, 100174.

16. Peisen Zhang, Yao Li, Xiaoqi Li, Yudong Wang, Hua Lin, Ni Zhang, Wenyue Li, Lihong Jing, Mingxia Jiao*, Xiliang Luo*, Yi Hou*. Shedding light on vascular imaging: the revolutionary role of nanotechnology. J. Nanobiotechnol., 2024, 22, 757.

17. Wenyue Li, Peisen Zhang*, Chuang Liu, Yuping Xu, Zhihua Gan, Lei Kang*, Yi Hou*. Oncogene-targeting nanoprobes for early imaging detection of tumor. J. Nanobiotechnol., 2023, 21, 197.

18. Peisen Zhang#, Yingying Cui#, Jian Wang#, Junwei Cheng, Lichong Zhu, Chuang Liu, Saisai Yue, Runxin Pang, Jiaoqing Guan, Bixia Xie, Ni Zhang, Meng Qin, Lihong Jing, Yi Hou, Yue Lan*. Dual-stimuli responsive smart nanoprobe for precise diagnosis and synergistic multi-modalities therapy of superficial squamous cell carcinoma. J. Nanobiotechnol., 2023, 21, 4.

19. Peisen Zhang, Yingying Li, Wen Tang, Jie Zhao, Lihong Jing*, Kevin J. McHugh*. Theranostic Nanoparticles with Disease-Specific Administration Strategies. Nano Today, 2022, 42, 101335.

20. Peisen Zhang#, Yicheng Feng#, Lichong Zhu, Kunyao Xu, Qiuhong Ouyang, Jianfeng Zeng, Feng Qin, Ni Zhang, Yuqing Wang, Fangfei He, Yufang Shi, Gang Chen, Zhe Shi, Meng Qin*, Yi Hou*, Mingyuan Gao*. Predicting thrombolytic haemorrhage risk of acute ischemic stroke through angiogenesis/inflammation dual-targeted MR imaging. Nano Today, 2023, 48, 101707.

21. Peisen Zhang, Wenyue Li, Chuang Liu, Feng Qin, Yijie Lu*, Meng Qin*, Yi Hou*. Molecular imaging of tumour-associated pathological biomarkers with smart nanoprobe: From “Seeing” to “Measuring”. Exploration, 2023, 3, 20230070.

22. Fangfei He, Lichong Zhu, Xiaohan Zhou, Peisen Zhang*, Junwei Cheng, Yuanyuan Qiao, Yicheng Feng, Saisai Yue, Man Xu, Jiaoqiong Guan, Xiaoming Li, Zhuo Ao, Meng Qin, Yi Hou, and Dong Han*. Red Blood Cell Membrane-Coated Ultrasmall NaGdF4 Nanoprobes for High-Resolution 3D Magnetic Resonance Angiography. ACS Appl. Mater. Interfaces, 2022, 14, 26372-26381.