性别

男

出生年月

1992.8

职称

特聘教授

学历（学位）

博士

所属院系

化学与分子工程学院

导师类别

博士生导师

招生专业

化学、基础医学、材料学等相关专业

研究方向

生命分析化学，分子影像，纳米医学

联系方式

  zhangps@qust.edu.cn

个人简历（包括近期科研项目）

张沛森，博士，青岛科技大学化学与分子工程学院特聘教授，硕士生导师，泰山学者青年专家。2015年获中南大学应用化学学士学位，2020年毕业于中国科学院化学研究所，获物理化学博士学位，2021-2013年于广州市第一人民医院/华南理工大学从事博士后研究。主要从事纳米探针的设计及其对重大疾病的多模态分子影像诊断和精准治疗研究。迄今，以第一/通讯作者在Nat.   Commun.，Sci. Adv.，Angew. Chem. Int. Ed.，ACS Nano，Adv. Funct. Mater.，Biomaterials，Anal. Chem.，The Innovation等国际重要期刊发表论文40余篇，合著发表论文60余篇。

科研项目

国家自然科学基金面上项目（2025-2028），主持

泰山学者青年专家项目（2025-2027），主持

国家重点研发计划青年科学家项目（2024-2029），项目骨干

国家自然科学基金青年项目（2022-2024），主持

中国博士后科学基金面上资助（2021-2023），主持

青岛科技大学人才引进启动资金（2024-2029），主持

代表性论文

1. Wenyue Li, Junwei   Cheng, Chuang Liu, Ni Zhang, Hua Lin, Fangfei He, Zhihua Gan, Peisen   Zhang*, Meng Qin*, Yi Hou*. Shine and darkle the blood vessels:   Multiparameter hypersensitive MR angiography for diagnosis of panvascular   diseases. Sci. Adv., 2024, 10, eadq4082.

2. Peisen Zhang^#, Junwei Cheng^#, Yijie Lu^#, Ni Zhang,   Xiaoai Wu, Hua Lin, Wei Li*, Jian Wang, Mitchell A. Winnik, Zhihua Gan*, Yi   Hou*. Hypersensitive MR Angiography based on Interlocking Stratagem for   Diagnosis of Cardiac-cerebral Vascular Diseases. Nat. Commun., 2023, 14, 6149.

3. Peisen Zhang^#, Jianfeng Zeng^#,   Yingying Li, Chen Yang, Junli Meng, Yi Hou*, Mingyuan Gao* Quantitative Mapping of Glutathione within   Intracranial Tumors through Interlocked MRI Signals of a Responsive Nanoprobe. Angew. Chem. Int. Ed., 2021, 60, 8130-8138.

4. Peisen Zhang, Yi Hou*, Jianfeng Zeng, Yingying Li, Zihua Wang, Ran Zhu,   Tiancong Ma, Mingyuan Gao*. Coordinatively Unsaturated Fe³⁺ Based   Activatable Probes for Enhanced MRI and Therapy of Tumors. Angew. Chem. Int. Ed., 2019, 58, 11088-11096.

5. Peisen Zhang, Lichong Zhu, Wenyue Li, Qiuhong Ouyang, Saisai Yue, Meng   Qin, Yi Hou*. Simultaneous Visualization of Anatomical Structure and   Molecular Pathology Variation in Vascular Inflammation with Informationized   Serum Albumin. ACS Nano, 2025, 19, 22109-22122.

6. Peisen Zhang^#, Yuanyuan Qiao^#, Lichong Zhu, Meng Qin, Qilong   Li, Chuang Liu, Yuping Xu, Xin Zhang, Zhihua Gan*, Yi Hou*. Nanoprobe Based on   Biominerals in Protein Corona for Dual-Modality MR Imaging and Therapy of   Tumors. ACS Nano, 2023, 17, 184-196.

7. Mingxia Jiao, Xiaoqi Li, Hui Liu, Peng Cai, Xiling Yang, Kevin   J. McHugh, Bowen Zheng, Jiachen Sun, Peisen Zhang*, Xiliang   Luo*, Lihong Jing*. Aqueous Grown Quantum Dots with Robust Near-Infrared   Fluorescence for Integrated Traumatic Brain Injury Diagnosis and Surgical   Monitoring. ACS Nano, 2024, 18, 19038-19053.

8. Wenyue Li, Junwei Cheng, Xinyi Zhang, Yuqing Wang, Shuai Wu,   Peisen Zhang*, Zhihua Gan, Yi Hou*. High-Resolution Magnetic   Resonance Angiography of Tumor Vasculatures with an Interlocking Contrast   Agent. ACS Nano, 2024, 18, 25647-25656.

9. Saisai Yue, Peisen Zhang*, Meng Qin, Lichong   Zhu, Yuanyuan Qiao, Qilong Li, Yijie Lu, Hao Wu, Ni Jiang, Chaoyong Liu,   Mitchell A. Winnik*, Yi Hou*. An Enzyme-Like Activity Nanoprobe Based on   Fe(III)–Rutin Hydrate Biomineral for MR Imaging and Therapy of Triple   Negative Breast Cancer. Adv. Funct. Mater., 2022, 32, 2202848.

10. Peisen Zhang, Yi'an Ran, Lei Han, Yao Li, Wanru Tian, Xiao Sun, Mingxia   Jiao*, Lihong Jing*, Xiliang Luo*. Nanomaterial technologies for precision   diagnosis and treatment of brain hemorrhage. Biomaterials, 2025, 321, 123269.

11. Peisen Zhang^#, Junwei Cheng^#, Chuang Liu^#, Wenyue   Li, Yuqing Wang, Ni Zhang, Jin Wu, Xinyu Zhang, Chaoyong Liu, Yi Hou*. Hypersensitive   MR Angiography for Diagnosis of Ischemic Stroke and Reperfusion Subarachnoid   Hemorrhage. Anal. Chem., 2024, 96, 11742-11750.

12. Wenyue Li, Mingxia Jiao, Yao Li, Shuai Wu, Peisen Zhang*, Xiliang   Luo*, Yi Hou*. Hypersensitive Multiparametric MRA for Mild Traumatic Brain   Injury: Simultaneous Imaging of Hemorrhagic Foci, Vascular Integrity, and   Collaterals. Anal. Chem., 2025, DOI: 10.1021/acs.analchem.4c06664.

13. Lina Zhu, Yuxi Zhang, Jiani Ding, Wenjuan Xin, Gao-Chao   Fan, Zhi-Ling Song*, Peisen Zhang*, Xiliang Luo*. Intelligent   DNA Nanosystem for Broad-Spectrum Oncological Typing and Therapy. ACS Sens., 2024, 9, 6655-6666.

14. Peisen Zhang, Junli Meng, Yingying Li, Chen Yang, Yi Hou, Wen Tang,   Kevin J. McHugh*, and Lihong Jing*, Nanotechnology-enhanced immunotherapy for   metastatic cancer. Innovation, 2021, 2,   100174.

15. Peisen Zhang, Yao Li, Xiaoqi Li, Yudong Wang, Hua Lin, Ni Zhang, Wenyue   Li, Lihong Jing, Mingxia Jiao*, Xiliang Luo*, Yi Hou*. Shedding light on   vascular imaging: the revolutionary role of nanotechnology. J.   Nanobiotechnol., 2024,   22, 757.

16. Peisen Zhang^#, Yingying Cui^#, Jian Wang^#, Junwei   Cheng, Lichong Zhu, Chuang Liu, Saisai Yue, Runxin Pang, Jiaoqing Guan, Bixia   Xie, Ni Zhang, Meng Qin, Lihong Jing, Yi Hou, Yue Lan*. Dual-stimuli responsive   smart nanoprobe for precise diagnosis and synergistic multi-modalities   therapy of superficial squamous cell carcinoma. J.   Nanobiotechnol., 2023,   21, 4.

17. Wenyue Li, Peisen Zhang*, Chuang Liu, Yuping   Xu, Zhihua Gan, Lei Kang*, Yi Hou*. Oncogene-targeting nanoprobes for early   imaging detection of tumor. J. Nanobiotechnol., 2023, 21, 197.

18. Peisen Zhang, Yingying Li, Wen Tang, Jie Zhao, Lihong Jing*, Kevin J.   McHugh*. Theranostic Nanoparticles with Disease-Specific Administration   Strategies. Nano Today, 2022, 42, 101335.

19. Peisen Zhang^#, Yicheng Feng^#, Lichong Zhu, Kunyao Xu, Qiuhong   Ouyang, Jianfeng Zeng, Feng Qin, Ni Zhang, Yuqing Wang, Fangfei He, Yufang   Shi, Gang Chen, Zhe Shi, Meng Qin*, Yi Hou*, Mingyuan Gao*. Predicting   thrombolytic haemorrhage risk of acute ischemic stroke through   angiogenesis/inflammation dual-targeted MR imaging. Nano Today, 2023, 48, 101707.

20. Fangfei He, Lichong Zhu, Xiaohan Zhou, Peisen Zhang*,   Junwei Cheng, Yuanyuan Qiao, Yicheng Feng, Saisai Yue, Man Xu, Jiaoqiong   Guan, Xiaoming Li, Zhuo Ao, Meng Qin, Yi Hou, and Dong Han*. Red Blood Cell   Membrane-Coated Ultrasmall NaGdF 4 Nanoprobes for High-Resolution 3D Magnetic   Resonance Angiography. ACS Appl. Mater. Interfaces, 2022, 14, 26372-26381.

21. Peisen Zhang, Mingxia Jiao, Yilin Li, Xiaoyan Ding*, Kevin J. McHugh*,   Lihong Jing*. Bright Semiconductor Quantum Dots Shed New Light on Precision   Nanomedicine for Various Diseases. Small Sci., 2024, 4, 2300081.

22. Peisen Zhang, Wenyue Li, Chuang Liu, Feng Qin, Yijie Lu*, Meng Qin*, Yi Hou*. Molecular imaging of tumour-associated pathological   biomarkers with smart nanoprobe: From “Seeing” to “Measuring”. Exploration, 2023, 3, 20230070.