工作和教育经历： 2020/09 - 至今，青岛科技大学，化学与分子工程学院，特聘副教授 2015/09 - 2020/06，山东师范大学，分析化学，博士 2011/09 - 2015/06，山东师范大学，化学，学士 2020年毕业于山东师范大学，获理学博士学位。致力于肿瘤标志物超灵敏检测的生物传感器研究，发展了一系列基于单分子检测、荧光检测、化学发光检测的生物传感器，并将其成功应用于检测各种 DNA、microRNA、蛋白质、酶和肿瘤细胞。以第一作者/并列一作在 Chemical Science、Analytical Chemistry、 Biosensors & Bioelectronics、 Chemical Communications、 Trends in Analytical Chemistry 等国际权威杂志发表 SCI 论文 28 篇，其中 Nature Index 文章 18 篇，中科院一区文章 17 篇。申请国家发明专利 8 项。主持科研项目有：山东省自然科学基金、青岛科技大学科研启动基金。 承担教学课程： 《基础化学原理实验B》 近期代表性论文： 1. Li, C. C.; Chen, H. Y.; Luo, X.; Hu, J.; Zhang, C. Y., Multicolor fluorescence encoding of different microRNAs in lung cancer tissues at the single-molecule level. Chem. Sci. 2021, 12 (37), 12407-12418. 2. Li, C. C.; Chen, H. Y.; Hu, J.; Zhang, C. Y., Rolling circle amplification-driven encoding of different fluorescent molecules for simultaneous detection of multiple DNA repair enzymes at the single-molecule level. Chem. Sci. 2020, 11 (22), 5724-5734. 3. Li, C. C.; Liu, W. X.; Hu, J.; Zhang, C. Y., A single quantum dot-based nanosensor with multilayer of multiple acceptors for ultrasensitive detection of human alkyladenine DNA glycosylase. Chem. Sci. 2019, 10, 8675-8684. 4. Li, C. C.; Hu, J.; Zou, X.; Luo, X.; Zhang, C. Y., Construction of a Structure-Switchable Toehold Dumbbell Probe for Sensitive and Label-Free Measurement of MicroRNA in Cancer Cells and Tissues. Anal. Chem. 2022, 94 (3), 1882-1889. 5. Li, C. C.; Hu, J.; Luo, X.; Hu, J.; Zhang, C. Y., Development of a Single Quantum Dot-Mediated FRET Nanosensor for Sensitive Detection of Single-Nucleotide Polymorphism in Cancer Cells. Anal. Chem. 2021, 93 (43), 14568-14576. 6. Li, C. C.; Dong, Y. H.; Zou, X. R.; Luo, X. L.; Shen, D. Z.; Hu, J.; Zhang, C. Y., Label-Free and Template-Free Chemiluminescent Biosensor for Sensitive Detection of 5-Hydroxymethylcytosine in Genomic DNA. Anal. Chem. 2021, 93 (4), 1939-1943. 7. Li, C. C.; Wang, Z. Y.; Wang, L. J.; Zhang, C. Y., Biosensors for epigenetic biomarkers detection: A review. Biosens. Bioelectron. 2019, 144, 111695. 8. Li, C. C.; Hu, J.; Lu, M. F.; Zhang, C. Y., Quantum dot-based electrochemical biosensor for stripping voltammetric detection of telomerase at the single-cell level. Biosens. Bioelectron. 2018, 122, 51-57. 9. Li, C. C.; Zhang, Y.; Tang, B.; Zhang, C. Y., Integration of single-molecule detection with magnetic separation for multiplexed detection of DNA glycosylases. Chem. Commun. 2018, 54 (46), 5839-5842. 10. Li, C. C.; Zhang, Y.; Liu, W. J.; Zhang, C. Y., A triple-amplification strategy for sensitive detection of telomerase at the single-cell level. Chem. Commun. 2018, 54 (67), 9317-9320. 11. Li, C. C.; Li, Y; Zhang, Y.; Zhang, C. Y., Single-molecule fluorescence resonance energy transfer and its biomedical applications. Trends Anal. Chem. 2020, 122, 115753. 12. 李琛琛，陈慧燕，董月红，罗细亮，胡娟，张春阳，表观遗传修饰——5-羟甲基胞嘧啶检测的研究进展. 化学学报 2021, 79 (5), 614-627. 13. Zhang, Y.; Li, C. C.; Zhang, X.; Xu, Q.; Zhang, C. Y., Development of Oxidation Damage Base-Based Fluorescent Probe for Direct Detection of DNA Methylation. Anal. Chem. 2020, 92 (15), 10223-10227. 14. Zhang, Y., Li, C. C.; Tang, B.; Zhang, C. Y., Homogeneously Sensitive Detection of Multiple DNA Glycosylases with Intrinsically Fluorescent Nucleotides. Anal. Chem. 2017, 89 (14), 7684-7692. 15. Ma, F.; Li, C. C.; Zhang, C. Y., Nucleic acid amplification-integrated single-molecule fluorescence imaging for in vitro and in vivo biosensing. Chem. Commun. 2021, 57 (99), 13415-13428. 16. Ma, F.; Li, C. C.; Zhang, C. Y., Development of quantum dot-based biosensors: principles and applications. J. Mater. Chem. B 2018, 6 (39), 6173-6190. 17. Cui, L.; Li, C. C.; Tang, B.; Zhang, C. Y., Advances in the integration of quantum dots with various nanomaterials for biomedical and environmental applications. Analyst 2018, 143 (11), 2469-2478. 18. Wang, L. J.; Han, X.; Li, C. C.; Zhang, C. Y., Single-ribonucleotide repair-mediated ligation-dependent cycling signal amplification for sensitive and specific detection of DNA methyltransferase. Chem. Sci. 2018, 9 (28), 6053-6061. 19. Hu, J.; Wang, Z. Y.; Li, C. C.; Zhang, C. Y., Advances in single quantum dot-based nanosensors. Chem. Commun. 2017, 53 (100), 13284-13295. 20. Zhang, Y.; Li, Q. N.; Li, C. C.; Zhang, C. Y., Label-free and high-throughput bioluminescence detection of uracil-DNA glycosylase in cancer cells through tricyclic cascade signal amplification. Chem. Commun. 2018, 54 (51), 6991-6994. |
