性别

   男

 出生年月

   1980.05

 职称/学历（学位）

   教授/博士

 所属院系

   化学与分子工程学院

 导师类别

   博士生导师

 行政职务

   无

 招生专业

   有机化学，应用化学

 研究方向

   有机合成和不对称催化反应研究

 联系方式

    Tel: 15810316691     e-Mail: lvjian@iccas.ac.cn

个人简历（包括近期科研项目）

吕健，教授（博导），山东省泰山学者青年专家，山东省杰青。近年来，在不对称双酸催化、手性碳正离子催化、自由基转化等研究邻域开展了大量的工作，并已在J. Am. Chem. Soc.（1篇），Angew. Chem. Int. Ed.（3篇），Sci. Chin. Chem.（1篇），Green Chem.（2篇），Chin. Chem. Lett.（4篇），Org. Lett.（22篇），Org. Chem. Front.（13篇），Chin. J. Chem.（1篇），Adv. Synth. Catal.（4篇），Chem. Commun.（1篇），Chem. Eur. J.（3篇），J. Org. Chem.（5篇）等国际一流学术期刊上发表了70余篇研究论文，授权中国发明专利12项。承担多项国家自然科学基金、山东省自然科学基金（省杰青）、山东省泰山学者青年专家、山东省科技型中小企业创新能力提升工程项目，中国科学院化学研究所培育项目、青岛科技大学科研启动基金、中国博士后科学基金特别资助等项目等。

研究方向：有机合成和不对称催化反应研究。

代表性文章目录：

1. Mengdie Tang, Man Wang, Songyang Li, Chenxi Guo, Ran Song, Daoshan Yang, and Jian Lv*, Switchable Chemoselectivity in [3 + 3] Annulation of β,γ-Unsaturated α-Ketoesters and 1H-Pyrazol-5-amines by Cooperative Acid Catalysis with NiII and InI, Org. Lett. 2024, doi: 10.1021/acs.orglett.4c02529 (JCR 1区).

2. Depeng Duan, Mengdie Tang, Man Wang, Huixin Qiu, Ran Song, Daoshan Yang, and Jian Lv*, Switchable Enantioselectivity in Conjugate Alkyne Addition of β,γ-Unsaturated α-Keto Esters by Asymmetric Binary Acid Catalysis, Org. Lett. 2024, 26, 3612-3616 (JCR 1区).

3. Man Wang, Juyan Zhang, Junda Zhao, Ran Song, Daoshan Yang, Long Zhang* and Jian Lv*, HfCl4–Phosphoric Acid Catalyzed Reduction of in situ Generated Carbocations with Hydrosilane: Facile Approaches to 2,4-Dihydrocyclopenta[b]indoles, Org. Chem. Front. 2024, doi: 10.1039/D4QO00874J (JCR 1区).

4. Wei Feng, Xiaoying Wu, Ran Song, Daosan Yang, Wen Si*, and Jian Lv*, Phenol-mediated Decarboxylative Proton Transfer of γ-Methylidene-δ-valerolactones: An Approach Towards (E)-2,4-Pentadienoates, Org. Chem. Front. 2024, 11, 2015-2020 (JCR 1区).

5. Yuan Tian, Mengdie Tang, Changshuo Lian, Ran Song, Daoshan Yang, and Jian Lv*, Asymmetric Binary-acid Catalysis: A Diastereo- and Enantioselective oxa-Nazarov Cyclization-Michael Addition of Conjugated 1,2-Diketones, Org. Chem. Front. 2023, 10, 3039-3044 (JCR 1区).

6. Huixin Qiu, Jiayi Ren, Long Zhang*, Ran Song, Wen Si, Daoshan Yang, Lirong Wen*, and Jian Lv*, Enantioselective Meerwein–Ponndorf–Verley Reduction of β,γ-Unsaturated α-Keto Esters by Asymmetric Binary-acid Catalysis in the Green Solvent iPrOH, Green Chem. 2023, 25, 3948-3955 (JCR 1区).

7. Man Wang, Ran Song, Daoshan Yang, and Jian Lv*. Asymmetric Binary Acid Catalysis: Switchable Enantioselectivity in Enantioselective Conjugate Hydride Reduction. Org. Lett. 2023, 25, 373-377 (JCR 1区).

8. Ran Song, Zhendong Lian, Wei Feng, Tianyi Guan, Wen Si*, Daoshan Yang, and Jian Lv*, Palladium-Catalyzed Decarboxylative O-Allylation of Phenols with γ-Methylidene-δ-valerolactones, Org. Chem. Front. 2022, 9, 4365-4371 (JCR 1区).

9. Man Wang, Rui Wang, Long Zhang, Wen Si, Ran Song, Daoshan Yang, and Jian Lv*, Efficient Radical C(sp3)–H α-Oxyamination of Carbonyls Adjacent to the Carbon Chalcogen Bond, Org. Chem. Front. 2022, 9, 3473-3479 (JCR 1区).

10. Man Wang, Ming Li, Long Zhang*, Ran Song, Daoshan Yang, and Jian Lv*, Photocatalytic Redox-neutral Reaction of γ-Indolyl α-Keto Esters, Org. Chem. Front. 2022, 9, 1875-1883 (JCR 1区).

11. Caiqi Zhuo, Ran Song, Zhanxu Liu, Qirui Xiang, Daoshan Yang, Wen Si*, and Jian Lv*, Silver(I)-Catalyzed Novel ipso-Cycloaddition and Retro-Friedel–Crafts Reaction of ortho-Hydroxyphenyl-substituted para- Quinone Methides, Org. Chem. Front. 2021, 8, 6400-6404 (JCR 1区).

12. Man Wang, Qirui Xiang, Wen Si, Ran Song, Daoshan Yang, Ming Li*, and Jian Lv*, Bioinspired Cyclization of in situ Generated γ-Indolyl β,γ-Unsaturated α-Keto Esters via an Oxidative Enamine Process: Facile Approaches to Pyrano[2,3-b]indoles, Org. Chem. Front. 2021, 8, 6337-6343 (JCR 1区).

13. Wenxuan Zhang, Jiaying Sun, Linrui Xiang, Wen Si, Ran Song, Daoshan Yang, and Jian Lv*, Binary-acid Catalysis with Sc(OTf)3/TfOH in the Alkenylation of Arenes with Alkynes, Org. Lett. 2021, 23, 5998-6003 (JCR 1区).

14. Man Wang, Long Zhang*, Wen Si, Ran Song, Ming Li*, and Jian Lv*, Neighboring Thioether Participation in Bioinspired Radical Oxidative C(sp3)–H α-Oxyamination of Pyruvate Derivatives, Org. Lett. 2021, 22, 8941-8946(JCR 1区).

15. Wansong Shang, Depeng Duan, Yongjun Liu, and Jian Lv*, Carbocation Lewis Acid TrBF4-Catalyzed 1,2-Hydride Migration: Approaches to (Z)-α,β-Unsaturated Esters and α-Branched β-Ketocarbonyls, Org. Lett. 2018, 21, 8013-8017 (JCR 1区).

16. Sujia Li, Jian Lv*, Sanzhong Luo*, Enantioselective Indium(I)-catalyzed [4+2] Annulation of Alkoxyallenes and β,γ-Unsaturated α-Keto Esters, Org. Chem. Front. 2018, 5, 1787-1791 (JCR 1区).

17. Qichao Zhang, Jian Lv*, Sujia Li, Sanzhong Luo*, Carbocation Lewis Acid Catalyzed Diels-Alder Reactions of Anthracene Derivatives, Org. Lett. 2018, 20, 2269-2272 (JCR 1区).

18. Le Wang, Jian Lv*, Long Zhang, and Sanzhong Luo*, Catalytic Regio- and Enantioselective [4+2] Annulation Reactions of Non-activated Allenes by a Chiral Cationic Indium Complex, Angew. Chem. Int. Ed. 2017, 56, 10867-10871 (JCR 1区).

19. Le Wang, Jian Lv*, Sujia Li, and Sanzhong Luo*, Divergent Coupling of ,γ-Unsaturated -Ketoesters with Simple Olefins: Vinylation and [2+2] Cycloaddition, Org. Lett. 2017, 19, 3366-3369 (JCR 1区).

20. Xingren Zhong, Jian Lv*, and Sanzhong Luo*, Enantio- and Diastereoselective Cyclopropanation of ,γ-Unsaturated -Ketoester by a Chiral Phosphate/ Indium(III) Complex, Org. Lett. 2017, 19, 3331-3334 (JCR 1区).

21. Xingren Zhong, Jian Lv*, and Sanzhong Luo*, Oxidative Radical Addition- Cyclization of Sulfonyl Hydrazones with Simple Olefins by Binary Acid Catalysis. Org. Lett. 2016, 18, 3150-3153 (JCR 1区).

22. Jian Lv, Qichao Zhang, Xingren Zhong, and Sanzhong Luo*, Asymmetric Latent Carbocation Catalysis with Chiral Trityl Phosphate, J. Am. Chem. Soc. 2015, 137, 15576-15583 (JCR 1区).

23. Xingren Zhong, Jian Lv*, and Sanzhong Luo*, [4+2] Cycloaddition of in Situ Generated 1,2-Diaza-1,3-dienes with Simple Olefins: Facile Approaches to Tetrahydropyridazines, Org. Lett. 2015, 17, 1561-1564 (JCR 1区).

24. Jian Lv, Long Zhang, and Sanzhong Luo*, Jin-Pei Cheng, Switchable Diastereoselectivity in Enantioselective [4+2] Cycloadditions with Simple Olefins by Asymmetric Binary Acid Catalysis, Angew. Chem. Int. Ed. 2013, 52, 9786-9790 (JCR 1区).

25. Jian Lv, Long Zhang, Yueming Zhou, Zongxiu Nie, Sanzhong Luo*, and Jin-Pei Cheng, Asymmetric Binary Acid Catalysis: A Regioselectivity Switch between Enantioselective 1,2- and 1,4-Addition through Different Counteranions of InIII, Angew. Chem. Int. Ed. 2011, 50, 6610-6614 (JCR 1区).

26. Jian Lv, Xin Li, Long Zhang, Sanzhong Luo*, and Jin-Pei Cheng, Asymmetric Binary-Acid Catalysis with Chiral Phosphoric Acid and MgF2: Catalytic Enantioselective Friedel-Crafts Reactions of ,γ-Unsaturated -Ketoesters, Org. Lett. 2010, 12, 1096-1099 (JCR 1区).

主持（负责人）科研项目情况：

1. 山东省科技型中小企业创新能力提升工程项目：具有改良的支化度分布的聚乙烯的研究（2023TSGC0704），7.5万，2023.07-2025.07，在研。

2. 山东省自然科学基金省杰青项目：不对称催化反应研究（ZR2020JQ07），100万，2021-至今，在研；

3. 山东省高等学校青创科技支持计划——不对称催化创新团队：不对称催化简单芳烃参与的环化反应研究（2019KJC003），20万，2019.01-2021.12，已结题；

4. 山东省泰山学者青年专家（tsqn201812075），100万，2019.01-2023.12，已结题；

5. 青岛科技大学引进人才启动基金，100万；

6. 国家自然科学基金面上基金项目：基于可控碳正离子的简单烯烃不对称环加成反应（21472193），85万，2015.01－2018.12，已结题；

7. 国家自然科学基金青年基金项目：不对称双酸催化杂原子邻位C(sp3)-H键氧化还原反应（21202170），25万，2013.01－2015.12，已结题。