出生年月

1984.10

政治面貌

无党派人士

职称

副教授

学历（学位）

博士（北京师范大学）

所属院系

化学与分子工程学院

教师类别

硕士生导师

行政职务

光电传感与生命分析教育部重点实验室副主任

招生专业

分析化学，应用化学，化学工程（专硕）

研究方向

分子成像；功能纳米材料；表面增强荧光；生化分析

联系方式

xushenghao@qust.edu.cn  

个人简历（包括近期科研项目）

2014年毕业于北京师范大学，获得分析化学博士学位，导师欧阳津教授。主要从事新型功能纳米探针的荧光分析体系构建及在生物传感中的应用研究，重点集中在精准分子成像、荧光高灵敏分析、表面增强荧光以及阵列分析等方向。在该领域的研究成果以第一或通讯作者在Nano Letters, Chemical Science, Analytical Chemistry, Chemical Communications等国际期刊上发表 SCI 论文 50余篇，其中分析化学领域权威期刊 Analytical Chemistry 15篇，授权国家发明专利3件，成果转化2件。作为项目负责人主持国家自然科学基金项目1项，山东省自然科学基金优青项目1项，面上项目1项，山东省高等学校优秀青年创新团队项目1项，获得山东省取得突出成绩博士后的表彰。相关研究工作获2020年山东省高等学校科学技术奖二等奖1项（第1位），2020年中国分析测试协会科学技术奖(CAIA奖)一等奖1项（第2位），2023年青岛市分析测试学会科学技术奖一等奖1项（第1位）。指导学生获批国家级大学生创新训练项目2项，全国大学生生命科学竞赛山东赛区一等奖1项，山东省科技创新大赛二等奖1项。

主持科研项目

国家自然科学基金青年基金（21505081），主持

山东省自然科学基金优青项目（ZR2019YQ13），主持

山东省自然科学基金面上项目（ZR2023MB110），主持

山东省高等学校优秀青年创新团队项目1项（2019KJC007），主持

承担教学课程

《物理化学实验》(本科生)、《发光分析》(研究生)

代表性论文

(1) Congkai Wang, Xiaohan Xu, Wang Yao, Lei Wang, Xiaozhe Pang, Shenghao Xu*, Xiliang Luo*, Programmable DNA Nanoswitch-Regulated Plasmonic CRISPR/Cas12a-Gold Nanostars Reporter Platform for Nucleic Acid and Non-Nucleic Acid Biomarker Analysis Assisted by a Spatial Confinement Effect, Nano Letters, 2025, 25, 1666-1672.

(2) Shuwei Chen, Yue Yin, Xiaozhe Pang, Congkai Wang, Lei Wang, Junqi Wang, Jiangfei Jia, Xinxue Liu, Shenghao Xu*, Xiliang Luo*, Light and endogenous enzyme triggered plasmonic antennas for accurate subcellular molecular imaging with enhanced spatial resolution, Chemical Science, 2024, 15, 566-572.

(3) Xiaozhe Pang, Haiming Li, Xiaohan Xu, Congkai Wang, Lei Wang, Wang Yao, Yaning Mao, Shenghao Xu*, Xiliang Luo*, Light-Triggered Plasmonic DNAzyme Walker Enables Precise Subcellular Molecular Imaging with Reduced Off-Mitochondria Signal Leakage, Analytical Chemistry, 2024, 96, 16971-16977.

(4) Yue Yin, Shuwei Chen, Haiming Li, Xiaozhe Pang, Congkai Wang, Lei Wang, Pingping Liu, Shenghao Xu*, Xiliang Luo*, Exogenous and Endogenous Dual-Activated Nanoladder for Precise Imaging of Mitochondrial Ferroptosis-Related Inhibition miRNA with Tumor Cell Specificity, Analytical Chemistry, 2024, 96, 7550-7557.

(5) Tingting Zhao, Xiaozhe Pang, Congkai Wang, Lei Wang, Yifan Yang, Junqi Wang, Jiangfei Jia, Xinxue Liu, Shenghao Xu*, Xiliang Luo*, Plasmonic Gold Nanostar-Based Probes with Distance Dependent Plasmon-Enhanced Fluorescence for Ultrasensitive DNA Methyltransferase Assay, Analytical Chemistry, 2024, 96, 4402-4409.

(6) Junhao Wang, Yuanyuan Liu, Tingting Zhao, Jiaheng Shi, Jing Chen, Dan, Li, Yanyun Cui, Shenghao Xu*, Xiliang Luo*, Enzymatically Activated Autonomous-Motion DNAzyme Signal Amplification Strategy for Tumor Cell-Specific Molecular Imaging with Improved Spatial Specificity. Analytical Chemistry, 2023, 95, 9388-9395.

(7) Tingting Zhao, Jiaheng Shi, Junhao Wang, Yanyun Cui, Yifan Yang, Shenghao Xu*, Xiliang Luo*, Fluorescence-Enhanced Dual-Driven “OR-AND” DNA Logic Platform for Accurate Cell Subtype Identification. Analytical Chemistry, 2023, 95, 3525-3531.

(8) Tingting Zhao, Xiaomei Sun, Jing Chen, Dan Li, Wei Cao, Shuwei Chen, Yue Yin, Shenghao Xu*, Xiliang Luo*, Optically Programmable Plasmon Enhanced Fluorescence-Catalytic Hairpin Assembly Signal Amplification Strategy for Spatiotemporally Precise Imaging. Analytical Chemistry, 2022, 94, 5399-5405.

(9) Jing Chen, Dan Li, Tingting Zhao, Junhao Wang, Jiaheng Shi, Shuwei Chen, Yue Yin, Shenghao Xu*, Xiliang Luo*, DNA Computation-Modulated Self-Assembly of Stimuli-Responsive Plasmonic Nanogap Antennas for Correlated Multiplexed Molecular Imaging. Analytical Chemistry, 2022, 94, 16887-16893.

(10) Dan Li, Tingting Zhao, Jing Chen, Jiaheng Shi, Junhao Wang, Yue Yin, Shuwei Chen, Shenghao Xu*, Xiliang Luo*, Spatiotemporally Controlled Ultrasensitive Molecular Imaging Using a DNA Computation-Mediated DNAzyme Platform. Analytical Chemistry, 2022, 94, 14467-14474.

(11) Jiaxiang Ding, Jiaheng Shi, Xiaomei Sun, Xin Lu, Xicheng Sun, Junhao Wang, Yuhang Ye, Shenghao Xu*, Xiliang Luo*, pH Programmed Optical Sensor Arrays for Cancer Plasma Straightforward Discrimination Based on Protein-Responsive Patterns. Analytical Chemistry, 2022, 94, 12546-12551.

(12) Tingitng Zhao, Yuhuan Gao, Jun Wang, YanyunCui, Shuyan Niu, Shenghao Xu*, Xiliang Luo*, From Passive Signal Output to Intelligent Response: “On-Demand” Precise Imaging Controlled by Near-Infrared Light. Analytical Chemistry, 2021, 93, 12329-12336.

(13) Yuhuan Gao, Jun Wang, Weina Wang, Tingting Zhao, Yanyun Cui, Pingping Liu, Shenghao Xu*, Xiliang Luo*, More Symmetrical “Hot Spots” Ensure Stronger Plasmon-Enhanced Fluorescence: From Au Nanorods to Nanostars. Analytical Chemistry, 2021, 93, 2480-2489.

(14) Jun Wang, Yuhuan Gao, Pingping Liu, Shenghao Xu*, Xiliang Luo*, Core-shell multifunctional nanomaterials based all-in-one nanoplatform for simultaneous multilayer imaging of dual types of tumor biomarkers and photothermal therapy. Analytical Chemistry, 2020, 92, 15169-15178.

(15) Shenghao Xu, Wentao Li, Xuan Zhao, Tong Wu, Yanyun Cui, Xinyue Fan, Wei Wang, Xiliang Luo*, Ultrahighly Efficient and Stable Fluorescent Gold Nanoclusters Coated with Screened Peptides of Unique Sequences for Effective Protein and Serum Discrimination. Analytical Chemistry, 2019, 91, 13947-13952.

(16) Shenghao Xu, Yongyin Nie, Liping Jiang, Jun Wang, Guiyun Xu, Wei Wang, Xiliang Luo*, Polydopamine Nanosphere/Gold Nanocluster (Au NC)-Based Nanoplatform for Dual Color Simultaneous Detection of Multiple Tumor-Related MicroRNAs with DNase-I-Assisted Target Recycling Amplification. Analytical Chemistry, 2018, 90, 4039-4045.

(17) Shenghao Xu, Xin Lu, Chenxi Yao, Fu Huang, Hua Jiang, Wenhao Hua, Na Na, Haiyan Liu, Jin Ouyang*, A Visual Sensor Array for Pattern Recognition Analysis of Proteins Using Novel Blue-Emitting Fluorescent Gold Nanoclusters. Analytical Chemistry, 2014, 86, 11634-11639.