导师姓名

张晓茹

性别

女

出生年月

1974.07

职称

教授

学历（学位）

博士

所属院系

化学与分子工程学院

导师类别

硕导

行政职务

教育部重点实验室副主任

招生专业

分析化学

研究方向

光电传感与生化分析

联系方式

15064250022

个人简历（包括近期科研项目）

学习研究经历、主要研究方向，取得主要成果、完成及承担的主要科研项目等。

于天津大学获学士和硕士学位，2003年毕业于中国海洋大学药物所获博士学位。研究内容涉电化学、化学发光、荧光及光致电化学等，近期主要包括激光共聚成像和拉曼成像研究，特别是细胞的成像研究。同时开展了新型功能化材料的研究如碳纳米管、石墨烯等。作为项目负责人承担国家自然科学基金三项：面上项目，65万元；青年-面上连续资助，80万元；青年基金，23万元。山东省重点研发项目一项，15万元；山东省中青年科学家奖励基金一项，6万元。中国海洋大学海洋药物教育部重点实验室开放基金，3万元。山东大学微生物技术国家重点实验室开放基金，2万元。获山东省科学技术自然科学二等奖一项（第二位），获山东省高校科研成果三等奖一项（第一位），获山东省高校科研成果一等奖两项（第二位）。近年作为第一作者或通讯作者在Chem. Sci., Anal. Chem., Chem. Commun.等国际著名学术期刊发表SCI论文20余篇，其中影响因子大于5.0的SCI论文20余篇。作为第一发明人授权国家发明专利两项。

近期发表主要文章：

1、Xiaoru Zhang, Ruijuan Li, Yuanyuan Chen, Shusheng Zhang,*Wenshuang Wang, and Fuchuan Li*, Applying DNA rolling circle amplification in fluorescence imaging of cell surface glycans labeled by a metabolic method, Chem. Sci.,2016,7,6182–6189.(IF 9.144)

2、X. R. Zhang, Y. Zhang, F. T. Chen, Y. Li, and S. S. Zhang. Visual detection of single-nucleotide polymorphisms and DNA methyltransferase based on cation-exchange of CuS nanoparticles and click chemistry of functionalized gold nanoparticles, Chem. Commun., 2016, 52, 13261-13264.（IF 6.834）

3、Ying Li, Chuanfeng Yu, Huixia Han, Caisheng Zhao,Xiaoru Zhang*,Sensitive SERS detection of DNA methyltransferase by target triggering primer generation-based multiple signal amplification strategy, Biosensors and Bioelectronics 2016, 81, 111–116.（IF 7.476）

4、Xiaoru Zhang, Hongxia Liu, Ruijuan Li, Ningbo Zhang, Ying Xiong, Shuyan Niu. Chemiluminescence detection of DNA/microRNA based on cation-exchange of CuS nanoparticles and rolling circle amplification,Chem. Commun.,2015,51, 6952-6955 (IF 6.718).（IF 6.834）

5、Wenshuang Wang, Naihan Han, Ruijuan Li, Wenjun Han,Xiaoru Zhang*, Fuchuan Li*, Supercharged Fluorescent Protein as a Versatile Probe for the Detection of Glycosaminoglycansin Vitro andin Vivo,Anal. Chem.2015, 87, 9302−9307(IF 5.636)

6、Xiaoru Zhang, Jiao Chen, Hongxia Liu, Shusheng Zhang. Quartz crystal microbalance detection of protein amplified by nicked circling, rolling circle amplification and biocatalytic precipitation,Biosensors and Bioelectronics65 (2015) 341–345. (IF 6.451)

7、Xiaoru Zhang, Mingshuai Liu, Yaning Mao, Yunpeng Xu, Shuyan Niu. Ultrasensitive photoelectrochemical immunoassay of antibody against tumor-associated carbohydrate antigen amplified by functionalized graphene derivates and enzymatic biocatalytic precipitation.Biosensors and Bioelectronics59 (2014) 21–27. (IF 6.451)

8、Xiaoru Zhang, Mingshuai Liu, Hongxia Liu, Shusheng Zhang, Low-toxic Ag2S quantum dots for photoelectrochemical detection glucose and cancer cells.Biosensors and Bioelectronics56 (2014) 307–312. (IF 6.451)

9、Xiaoru Zhang, Yunpeng Xu, Yanqing Zhao, Weiling Song, A new photoelectrochemical biosensors based on DNA conformational changes and isothermal circular strand-displacement polymerization reaction,Biosensors and Bioelectronics, 2013, 39, 338–341. (IF 6.451).

10、Xiaoru Zhang, Yingshu Guo, Mingshuai Liu and Shusheng Zhang, Photoelectrochemically active species and photoelectrochemical biosensors,RSC Adv., 2013, 3, 2846–2857. (IF 3.708)

11、Xiaoru Zhang, Yunpeng Xu, Yanqiang Yang, Xia Jin, Sujuan Ye, Shusheng Zhang, and Lilin Jiang. New Signal-On Photoelectrochemical Biosensor Based on a Graphene/Quantum-Dot Nanocomposite Amplified by the Dual- Quenched Effect of Bipyridinium Relay and AuNPs，Chem. Eur. J. 2012, 18, 16411 – 16418. (IF 5.696).

12、Xiaoru Zhang, Yanqing Zhao, Huanran Zhou, Bin Qu, A new strategy for photoelectrochemical DNA biosensor using chemiluminescence reaction as light source,Biosensors and Bioelectronics26 (2011) 2737–2741. (IF 6.451).

13、Xiaoru Zhang, Shuguo Li, Xia Jin, Xuemei Li, Aptamer based photoelectrochemical cytosensor with layer-by-layer assembly of CdSe semiconductor nanoparticles as photoelectrochemically active species,Biosensors and Bioelectronics 26 (2011) 3674–3678. (IF 6.451).

14、Xiaoru Zhang, Shuguo Li, Xia Jin, Shusheng Zhang, A new photoelectrochemical aptasensor for the detection of thrombin based on functionalized graphene and CdSe nanoparticles multilayers,Chem. Commun., 2011, 47, 4929–4931. (IF 6.718).

15、Xiaoru Zhang, Yanqing Zhao, Shuguo Li, Shusheng Zhang, Photoelectrochemical biosensor for detection of adenosine triphosphate in the extracts of cancer cells,Chem. Commun., 2010, 46, 9173–9175. (IF 6.718).

16、Xiaoru Zhang, Ying Li, Haoran Su, Shusheng Zhang, Highly sensitive and selective detection of Hg²⁺using mismatched DNA and a molecular light switch complex in aqueous solution.Biosensors and Bioelectronics, 2010, 25(6), 1338-1343. (IF6.451).

17、Xiaoru Zhang, Huanran Zhou, Caifeng Ding, Shusheng Zhang, A dicopper complex chemiluminescence probe for the determination of thiols in the extracts of murine P388 lymphocytic leukemia cell,Chem Commun, 2009, 5624-5626. (IF6.718).

18、Xiaoru Zhang, Haoran Su, Sai Bi, Shuguo Li, Shusheng Zhang, DNA-based amplified electrical bio-barcode assay for one-pot detection of two target DNAs,Biosensors and Bioelectronics, 2009, 24(8), 2730-2734. (IF 6.451).

19、Xiaoru Zhang, Baoping, Qi, Shusheng Zhang, Amplified electrochemical aptasensor for thrombin based on bio-barcode method,Biosensors and Bioelectronics, 2009, 25,259-262. (IF 6.451).

20、Weiling Song，Yawen Luan，Xiaoyan Guo，Peng He，Xiaoru Zhang*，Sensitive detection of DNA methyltransferase using the dendritic rolling circle amplification-induced fluorescence，Analytica Chimica Acta，2017, 956, 57-62. (IF 4.712)

21、Xiaoru Zhang, Fengting Chen, Xiaojie Song, Peng He, Shusheng Zhang, Proximity ligation detection of lectin Concanavalin A and fluorescence imaging cancer cells using carbohydrate functionalized DNA-silver nanocluster probes，Biosensors and Bioelectronics104 (2018) 27–31. (IF 8.173).

22、Ying Li, Fengting Chen, Zhenzhu Luan,Xiaoru Zhang*, A versatile cathodic “signal-on” photoelectrochemical platform based on a dual-signal amplification strategy,Biosensors and Bioelectronics119 (2018) 63–69. (IF 8.173).